Monday, January 21, 2013

Microbial Hermeneutics - 3

Microbes are talking with human cells.
One of the hypotheticals of Toxins of Power, the subject of this blog, is that there is a metamorphosis which takes place in most of those who are exposed to social power (About Toxins Of Power).

While trying to search the Earth and the Universe for the source of the toxins of power that may, in whole or in part, cause that metamorphosis, the Toxins of Power Blog came upon prions, phages, machines, and microbes that are "doing their thing" within the human species.

Upon encountering them, we stumbled upon their ability and practice of communication between and among themselves, as well as their ability and practice of communicating with human cells.

In this series, Microbial Hermeneutics, we have been discussing not only the communication between and among microbes, but we have also been discussing their usage of something we humans also use: hermeneutics.

For a discussion of human hermeneutics see "Hermeneutics For The Blogosphere" and "His Or Hermeneutics?," two Dredd Blog posts that deal with several types of human hermeneutics.

Since hermeneutics is a science concerning the interpretation of communicated messages, and since (like us) cells of all types within our bodies communicate through signals, it became at once obvious to me that a viable hermeneutics that focuses on the inner microbial world of communication is important:
An alternative view is that cells use simpler ‘‘rules’’ to determine
appropriate gene expression levels in response to conflicting signals. But what do these ‘‘rules’’ look like, how complex are they, and to what extent can they be used to predict the response of cells to novel signal combinations?
These issues are increasingly critical throughout biomedical science. Single-cell organisms such as bacteria can live in extraordinarily diverse environments, in and out of hosts, and surrounded by other microbial species and the antibiotics that many of them produce. In this milieu, signal integration abilities are critical to survival. Similarly, in metazoan development, individual signaling pathways rarely work in isolation; rather, cellular responses depend on combinations of inputs from multiple pathways ...
(Microbial Hermeneutics). Signal integration is a vast subject, however, it basically boils down to making sense out of multiple signals.

Which is also the basic task of human hermeneutics (human words, whether spoken, sung, or written are basically signals which need to be interpreted).

Let's also consider that the opposite of signal integration or hermeneutics is miscommunication caused by signal disruption.

However, before we delve a bit into signal disruption or impaired hermeneutics, let's seriously note that the value of microbial and other cellular heremeneutics should not be underestimated:
Normal, healthy cells only reproduce when there is enough space for them to fit. The body can regulate the production of cells by sending signals when to stop. With leukemia, these cells do not respond to the signals to stop and reproduce, regardless of space available.
(Pediatric Leukemia, emphasis added). In the context of microbial cell to cell communication, not responding to signals is a function of either not having received a message in the first place, or of not properly interpreting that signal (note: not responding is only bad when a response to that signal is required).

By taking into consideration childhood leukemia such as acute lymphoblastic leukemia [ALL], we see the results of an absence of adequate cellular or microbial signaling, cellular hermeneutics, or both.

The ultimate nature of signaling fundamentally requires: a signal, a signal sender, a signal receiver, a medium within which the signal can be sent, and an understanding of the particular signal by both sender and receiver.

Thus, we see that the glue which holds communication together is a signaling language that is understood by both the signal sender and the signal receiver.

To thwart communication, a signal disruptor can attack the signal itself during signal transport, or can attack either the sender, the receiver, or both, so that there is a defective signal or a defective hermeneutic episode as to that signal.

A disruption anywhere in that signal chain can result in a misunderstanding, a failure to successfully communicate.

In this sense, we can define some diseases as a failure to successfully communicate, as with the form of leukemia they call "ALL", mentioned above.

The Dredd Blog post, Childhood Leukemia Linked To Government Carelessness, discusses a scenario where, according to the perspectives of this blog, the toxins of power have corrupted those in seats of political power who have then corrupted the signalling abilities of the type this post is concerned with.

That is, the toxins of power have caused those officials in positions of power to unleash signal disruptors, in the form of deadly nuclear radiation, on the populace (There is no safe level of Radiation).

Those disruptors are known to then cause leukemia and other maladies in both adults and children.

In future posts of this series I want to take a look at, yes, focus on that disruption, that is, I want to take a look at, or to pose questions about, which specific areas in that specific signal / communication chain are disrupted or damaged by nuclear power plant radiation.

In theory, that disruption could involve damage to the machines within cells, whether human or microbial cells, damage to their signal sending capacity, damage to their signal receiving capacity, damage to the medium outside those cells -- through-which signals must travel -- or even damage to the hermeneutical abilities of the receiver cell.

The previous post in this series is here.

More signals are coming in future posts, but in the mean time you might enjoy hearing from some of the scientific teams that are able to talk to microbes -- (they know the language of microbes):

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